Bis iodide

Bismuth Triazide, Bi(Ns)j, mw 335.07, N 37.63%. The prepn of this compd was attempted by Vournazos (Ref 1) who treated Bi iodide with an equimolar part of Na azide. The following reaction occurred 2 Bi I, + 2 NaNj + Ha0 - BiOI + Bil + 2HNa + 2NaI and with twice this amt of Na azide Bila + 2NaNs + HaO - BiOI + 2Nal + 2HN,. It was thought by Vournazos that an unstable bismuth iodo-diazide, Bi I(Ns)a, was formed but immediately hydrolyzed (Ref 2)... 

Bismuth Triazide, Bi(N,), mw 335.07, N 37.63%. The prepn of this compd was attempted by Vournazos (Ref 1) who treated Bi iodide with an equimolar part of Na azide. The following reaction occurred 2 Bi I, + 2NaN,... 

As an alternative method, the highly strained enediyne system 163 was constructed by the coupling of the alkynyl bis-iodides 161 with (Z)-bis(trimethylstannyl)ethylene (162) [75], No cyclization occurs when there is the double bond, instead of the epoxide. 

Boron sub-iodide, B2I4, is prepared by the action of an electrical discharge on BI vapour. 

Usually, iodides and bromides are used for the carbonylation, and chlorides are inert. I lowever, oxidative addition of aryl chlorides can be facilitated by use of bidcntatc phosphine, which forms a six-membered chelate structure and increa.scs (he electron density of Pd. For example, benzoate is prepared by the carbonylation of chlorobenzene using bis(diisopropylphosphino)propane (dippp) (456) as a ligand at 150 [308]. The use of tricyclohexylphosphine for the carbonylation of neat aryl chlorides in aqueous KOH under biphasic conditions is also recommended[309,310]. 

Other Radioprotective Chemicals. The bis-methylthio- and methylthioamino-derivatives of 1-methylquinolinium iodide and l-methylpyridinium-2-dithioacetic acid provide reasonable protection to mice at much lower doses than the aminothiols, which suggests a different mechanism of action (139). One of these compounds, the 2-(methylthio)-2-piperidino derivative of the l-methyl-2-vinyl quinolinium iodide (VQ), interacts with supercoUed plasmic DNA primarily by intercalation. Minor substitutions on the aromatic quinolinium ring system markedly influence this interaction. Like WR-1065, VQ is positively charged at physiological pH, and the DNA-binding affinities of VQ and WR-1065 appear to be similar. 

The enhancement of the electrophilic properties of thaHium(III) ttifluoroacetate makes it a very important thaHation reagent. The products of thaHation, eg, arylthaHium bis(ttifluoracetate), undergo a variety of substitution reactions, yielding iodides, fluorides, nitriles, thiophenols, phenols, and biaryls. 

BCl, BBr, and BI undergo exchange reactions to yield mixed boron hahdes. Exchange reactions also occur with trialkyl, triaryl, trialkoxy, or triaryloxy boranes and with diborane. Anhydrous metal bromides and iodides can be prepared by the exchange reaction of the metal chloride or oxide and BBr or BI (21)-... 

Both thermal and Hilbert-Johnson reactions occur quite readily in 2- and 4/6-alkoxyquinazolines. For example, distillation of 2,4-bis-/3-diethylaminoethoxyquinazoline in vacuo yields l,3-bis-/3-diethylaminoethylquinazolin-X4(l/J,3H )-dione (60JCS3546). A complicated example is furnished by heating a tetramethoxybipyrimidine with methyl iodide to give four separable products progressively (81AJC1157). 

The 2- and 4-alkylthioquinazolines are formed by the second or third of the above methods as appropriate. For example, quinazoline-2(l//)-thione and methyl iodide/alkali give the thioether (883) and the 4-thioether is made similarly (62JCS3129) 2,4-dichloroquinazoline and sodium p-chlorothiophenate give 2-chloro-4-p-chlorophenylthio-(884 R = C1) or 2,4-bis-p-chlorophenylthio-quinazoline (884 R = SC6H4C1) according to conditions (48JCS1766). 

Pyridinium iodide, 4,4 (l,3,4-thiadiazole-2,5-diyl)-bis(l-methyl)-reduction, 6, 564 Pyridinium ion, Af-methyl-as metabolite of pyridine, 1, 234 Pyridinium ions hydrogen bonding to water mass spectrometry, 2, 135 magnetic circular dichroism, 2, 129 NMR, 2, 121... 

Bi,Sr,CaCu,03 g + (2y-12)T 2BF++ 2Sr -"+ Ca -"+ 2CuI + yO -+ (y-7)I, In this ease the exeess of aside solution and potassium iodide solution are added to analyzing eompound with eontinuous stirring. The generated iodine is titrated by Na3S,03 solution. The ealeulation of oxygen index (y) is eaiTying out by formula ... 

Blanchard and Simmons suggested that the stable organozinc intermediate obtained in this reaction is probably bis-(iodomethyl) zinc zinc iodide (1). 

Bis-(iodomethyl)zinc-zinc iodide, 108 17 a,20 20,21-Bismethylenedioxy- U,2 -di-hydroxypregn-4-ene-3,11 -dione, 425 17a,20 20,21-Bismethylenedioxy-3,3-ethyl-enedioxy-5a,6a-oxidopregnan-l 1-one and 5 3,6p-oxide, 3... 

Copper-mediated coupling of the aryl iodide derived from l,3-bis(2-hydroxy-hexafluoroisopropyl)benzene with perfluorooctyl iodide gives the desired compound as a dimethyl sulfoxide (DMSO) complex [166] (equation 143) Even bromoarenes can be coupled [167] (equation 144)... 

The photochemical or thermal reaction between petfluoroalkyl iodides and mercury-cadmium amalgams has been used for the synthesis of perfluoro-alkylmercury compounds [150] Functionalized analogues have been prepared similarly via this route [151, 152] (equation 117), and the preparation of bis(tri-fluoromethyl)mercury has been described [153]... 

Codeposition of silver vapor with perfluoroalkyl iodides at -196 °C provides an alternative route to nonsolvated primary perfluoroalkylsilvers [272] Phosphine complexes of trifluaromethylsilver are formed from the reaction of trimethyl-phosphme, silver acetate, and bis(trifluoromethyl)cadmium glyme [755] The per-fluoroalkylsilver compounds react with halogens [270], carbon dioxide [274], allyl halides [270, 274], mineral acids and water [275], and nitrosyl chloride [276] to give the expected products Oxidation with dioxygen gives ketones [270] or acyl halides [270] Sulfur reacts via insertion of sulfur into the carbon-silver bond [270] (equation 188)... 

The scope of haloaliphatic additions to alkenes has been extended to the preparation of 1,2-bis(perfluoroalkyl)iodoethanes by the addition of perfluoroalkyl iodides tofluoroalkyl alkenes [73] (equation 12) or to alkadienes [14] (equation 13)... 

The treatment of LiN(SiMc3)2 with aryl tellurenyl iodides gives stable Ai,iV -bis(trimethylsilyl)tellurenamides that react with acetylenes to give acetylenyl tellurides (Eq. 2.4). 

Final structure determination of the monomethyl derivatives was made possible only on performing straightforward syntheses of the compounds, analogous to syntheses of allantoxaidine. The 1-methyl (19) and 3-methyl (20) derivatives were prepared by cyclization of 1- and 3-methyl biuret,respectively. The 3-methyl derivative was also obtained by cyclization of A ,A -bis(methylcarbamyl)formami-dxne. The 1-methyl derivative was the same as the product obtained by Biltz on methylation of silver salt of allantoxaidine with methyl iodide. The same product is formed primarily during methylation of dioxotriazine with diazomethane. An excess of this agent produces the expected 1,3-dimethyl derivative (21). These results of alkyl-... 

Kalir and Szara obtained l,3-bis(a-chloropropionyl)indole (140) by the action of a 20% excess of a-chloropropionyl chloride on indole magnesium bromide in an ether-toluene mixture. On the other hand, Ganellin and Ridley obtained 3-(o -chloropropionyl)indole (141) by the action of a 10% excess of a-chloropropionyl chloride on indole magnesium iodide in anisole. -... 

In 1961 Acheson and Hands obtained 3-methyl-l-(2-nitroethyl)-indole (354) in low yield by the addition of nitrocthylene to 3-methyl-indole magnesium iodide. These authors also obtained 5-benzyloxy-l,3-bis(2-nitroethyl)iiidole (355) and 5,6-dimethoxy-3-(2-nitroethyl)-indolo (356) by the action of nitrocthylene on 5-henzyloxy- and 5,G-dimethoxyindolc magnesium iodide, respectively. They excluded the ]jossibility that the products 354, 355, and 356 had the isomeric indolenine structures on the basis of their absorption spectra and chemical properties. 

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