Biotechnology 2.3- butanediol production

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Itoh, N., Nakamura, M., Inoue, K. and Makino, Y. (2007) Continuous production of chiral 1,3-butanediol using immobilized biocatalysts in a packed bed reactor promising biocatalysis method with an asymmetric hydrogen-transfer bioreduction. Applied Microbiology and Biotechnology, 75 (6), 1249-1256. 

Celinska E, Grajek W. (2009). Biotechnological production of 2,3-butanediol-current state and prospects. Biotechnol Adv, 27,715-725. 

Shen MQ, Ji XJ, Nie ZK, Xia ZF, Yang H, Huang H. (2013). Biotechnological production of 2,3-butanediol stereoisomers synthetic mechanism and realized methods. Chin J Catal, 34, 351-360. 

With many great advances made over the years, SA production is at the stage of commercialization. Several companies, such as Reverdia, Bioamber, Myriant, and Succinity, have initiated or are about to start the large-scale production of SA [1]. Furthermore, transformation of bio-based SA into other valuable chemicals such as 1,4-butanediol and tetrahydrofuran is being carried out by these companies, demonstrating that the microbial SA production is a successful example of industrial biotechnology. 

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