Biotechnology biocatalysis

Delft University of Technology Department of Biotechnology Biocatalysis and Organic Chemistry Julianalaan 136 2628BL Delft The Netherlands... 

Subjects LCSH Enzymes-Biotechnology. Biocatalysis. Green chemistry. BISAC TECHNOLOGY ENGINEERING /... 

Stuckey, D. C., Caridis, K. A., Leak, D. J., Kinetics of Mycobacterium M156 for chiral biotransformations. Biotechnology 94, Indlnt. Symp. on Applied Biocatalysis, Brighton, pp.37-39, 1994. 

Nowadays biocatalysis is a well-assessed methodology that has moved from the original status of academic curiosity to become a widely exploited technique for preparative-scale reactions, up to the point that the so-called industrial biotechnology (to which biocatalysis contributes to the most extent) is one of the three pillars of the modern sustainable chemistry. 

Gotor-Fernandez, V., ReboDedo, F. and Gotor, V. (2007) Preparation of chiral pharmaceuticals through enzymatic acylation of alcohols and amines, in Biocatalysis in the Pharmaceutical and Biotechnology Industry, (ed. R.M. Patel), Dekker, Taylor and Francis, New York, Chapter 7, pp. 203-248. 

Patel, R.N. (2007) Biocatalysis in the Pharmaceutical and Biotechnology Industries, CRC Press, Boca Raton. 

Patel, R.N. (ed.) (2007) Biocatalysis in the Pharmaceutical and Biotechnology Industries, CRC Press, Boca Raton. Aehle, W. (ed.) (2007) Enzymes in Industry, 3rd edn, Wiley-VCH GmbH Co., KGaA., Weinheim. 

A.G.J. Voragen and W Pilnik, In J.R. Whitacker and P.E. Sonnet (eds.) Biocatalysis in Agricultural Biotechnology, ACS Symposium Series, Volume 389, American Chemical Society, Washington, DC, 1989. 

Kragl, 1J., Kruse, W., Hummel, W. and Wandrey, C. (1996) Enzyme engineering aspects of biocatalysis cofactor regeneration as example. Biotechnology and Bioengineering, 52, 309-319. 

Woodley, J.M. (2008) New opportunities for biocatalysis making pharmaceutical processes greener. Trends in Biotechnology, 26 (6), 321-327. 

Zhao, H.M., Chockalingam, K. and Chen, Z.L. (2002) Directed evolution of enzymes and pathways for industrial biocatalysis. Current Opinion in Biotechnology, 13, 104—110. 

Itoh, N., Nakamura, M., Inoue, K. and Makino, Y. (2007) Continuous production of chiral 1,3-butanediol using immobilized biocatalysts in a packed bed reactor promising biocatalysis method with an asymmetric hydrogen-transfer bioreduction. Applied Microbiology and Biotechnology, 75 (6), 1249-1256. 

Azerad, R. (2007) Biotransformation of natural or synthetic compounds for the generation of molecular diversity, in Biocatalysis in the Pharmaceutical and Biotechnology Industries (ed. R.N. Patel), CRC Press Boca Raton, FL, pp. 273-297. 

Boyd, D.R., Sharma, N.D. and Allen, C. (2000) Aromatic dioxygenases molecular biocatalysis and applications. Current Opinion in Biotechnology, 12, 564—573. 

Biocatalysis is an emerging and transformational technology uniquely suited to the manufacture of active ingredients in the pharmaceutical and related industries as a result of recent breakthroughs in biotechnology exponential growth in publicly available sequences from the gene... 

One of the most actively investigated aspects of the biohydrolysis of carboxylic acid esters is enantioselectivity (for a definition of the various stereochemical terms used here, see [7], particularly its Sect. 1.5) for two reasons, one practical (preparation of pure enantiomers for various applications) and one fundamental (investigations on the structure and function of hydrolases). The synthetic and preparative aspects of enantioselective biocatalysis by hydrolases have been extensively investigated for biotechnology applications but are of only secondary interest in our context (e.g., [16-18], see Sect. 7.3.5). In contrast, the fundamental aspects of enantioselectivity in particular and of structure-metabolism relationships in general are central to our approach and are illustrated here with a number of selected examples. 

For some recent reviews on the use of enzymes in nonconventional media, see (a) Dreyer, S., Lembrecht, J., Schumacher, J. and Kragl, U., Enzyme catalysis in nonaqueous media past, present, and future in biocatalysis in the pharmaceutical and biotechnology industries, 2007, CRC Press, pp. 791-827 . (b) Torres, S. and Castro, G.R., Non-aqueous biocatalysis in homogeneous solvent systems. Food Technol. BiotechnoL, 2004, 42, 271-277 (c) Carrea, G. and Riva, S., Properties and synthetic applications of enzymes in organic solvent. Angew. Chem. Int. Ed., 2000, 39, 2226-2254. 

Venkitasubramanian, P., Daniels, L. and Rosazza, J.P.N., Biocatalytic reduction of carboxylic acids mechanism and application. In Biocatalysis in the Pharmaceutical and Biotechnology Industries, Patel, R. (ed). CRC Press LLC Boca Raton, FL, 2006, pp. 425-440. 

Vofi H,Miethe P (1992) Enzymes entrapped in liquid crystals a novel approach for bio-catalysis in nonaqueous media. In Tramper J, Vermae MH, Beet HH, Stockar UV (eds) Biocatalysis in non-conventional media, progress in biotechnology. Elsevier, London 8 739... 

---