Biosynthesis microorganisms

For the investigation of ergochrome biosynthesis, microorganisms were required which produce ergochromes steadily and which accept labeled precursors efficiently. Lichens as Parmelia entotheiochroa, which grow extremely... 

Biosynthesis ofS(— )-M llc Acid. Aqueous fumaric acid is converted to levorotatory malic acid by the intracellular enzyme, fumarase, which is produced by various microorganisms. A Japanese process for continuous commercial production of S(—)-mahc acid from fumaric acid is based on the use of immobilized Brevibacteriumflavum cells in carrageenan (32). The yield of pyrogen-free S(—)-mahc acid that is suitable for pharmaceutical use is ca 70% of the theoretical. 

Microorganisms requite several minerals such as ferrous and potassium ions which play important roles in glutamic acid fermentation. Other important culture conditions include regulating aeration stirring. The biosynthesis of L-glutamic acid is performed under regulated aerobic conditions. 

The majority of PH As biosynthesis is performed by various microorganisms, especially bacteria. They can produce PHAs from a number of substrates and accumulate in their cells as carbon source and energy reserve under imbalanced growth conditions such as nutrient limitation. Fig.7 shows PHA accumulated in their cells that are characterized by transmission electron microscopic (TEM) technique. 

The simple nutritional requirements and metabolic adaptability of many common saprophytic spoilage microorganisms enable them to utilize many of the components of medicines as substrates for biosynthesis and growth, including not only the intended... 

Meganathan, R., Ubiquinone biosynthesis in microorganisms, FEMSMicrobiol Lett., 203, 131, 2001. 

Introduces novel approaches to the biosynthesis of colorants by microalgae, microorganisms, and genetic engineering... 

Iron transport agents may belong to the protein or non-protein class. In the former group are found the animal proteins transferrin (25), lactoferrin (26) and conalbumin (27). The low molecular weight iron carrying compounds from microorganisms, the siderochromes, may occur with or without a bound metal ion. Typically, severe repression of biosynthesis of these substances can be expected to set in at an iron concentration of ca. 2 x 10-5 g atoms/liter (28). Most, but not all, of these substances can be described as phenolates or hydroxamates (4). 

Hutchinson, C.R. and McDaniel, R. (2001) Combinatorial biosynthesis in microorganisms as a route to new antimicrobial, antitumor and neuroregenerative drugs. Current Opinion in Investigational Drugs, 2, 1681. 

Kojic acid, 5-hydroxy-2-(hydroxymethyl)-4//-pyran-4-one1 (II), is produced from carbohydrate sources in an aerobic process by a variety of microorganisms. The acid was discovered in 1907, its structure was established in 1924, and its chemical synthesis from D-glucose was achieved in 1930. Since then, a considerable amount of study has been devoted to the biosynthesis of kojic acid, and numerous publications have dealt with its chemical and biological properties. After nearly half a century, kojic acid remains a scientists curiosity, without industrial importance. It con-... 

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