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Bioseparations extracellular products

Techniques used in bioseparations depend on the nature of the product (i.e., the unique properties and characteristics which provide a handle for the separation), and on its state (i.e., whether soluble or insoluble, intra- or extracellular, etc.). All early isolation and recovery steps remove whole cells, cellular debris, suspended solids, and colloidal particles, concentrate the product, and, in many cases, achieve some degree of purification, all the while maintaining high yield. For intracellular compounds, the initial harvesting of the cells is important... [Pg.2056]

The product may be located inside a microorganism (intracellular) or outside in the growth medium (extracellular), or alternatively, the product could be the whole cell material. The nature of the product may be solid or dissolved in the aqueous phase. For example, the product is found in the aqueous phase for a fuel ethanol fermentation, within the cell for a therapeutic protein, while the product is the whole cell in the case of single cell protein. The location of the product influences the choice of a bioseparation method which may favor the efficient recovery of either the solid or liquid phase. The relative difficulty of separating intracellular products from other unwanted insoluble materials may influence the subsequent processing steps once the solids phase has been recovered from the fermentation broth. [Pg.637]

In a bioprocess the desired end product may be present as whole cells or intracellular or extracellular material at the end of a fermentation. Therefore in this first bioseparation stage, it may be necessary to recover either the solid or aqueous phase, with as much of the unwanted phase removed as possible, and with minimal loss of the desired material to maximize product yield. [Pg.639]


See other pages where Bioseparations extracellular products is mentioned: [Pg.93]    [Pg.221]    [Pg.850]    [Pg.73]    [Pg.175]    [Pg.2228]    [Pg.2212]    [Pg.93]    [Pg.684]   
See also in sourсe #XX -- [ Pg.847 ]




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