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Stoichiometric bioscavengers

Protection From Organophosphorus Intoxication by Stoichiometric Bioscavengers... [Pg.47]

A promising advance was made with the application of gene therapy for introducing catalytic and stoichiometric bioscavengers in vivo. It was shown that recombinant adenoviruses containing genes for Hu PONl when administered into mice boosted PONl levels in blood. Similarly, the... [Pg.165]

Many approaches have been made to improve the efficacy of stoichiometric bioscavengers. Enzymes that can hydrolyze OP are also being considered as promising bioscavengers. These efforts are summarized below ... [Pg.213]

Thus, the cholinesterases can be used not only as stoichiometric bioscavengers, but also as therapeutic proteins that are capable of preventing both the acute presentation and chronic dysmorphology and immunosuppression of OP toxicity. [Pg.773]

Mumford, H., Docx, C.J., Price, M.E., et al, 2013. Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. Chem. Biol. Interact. 203, 160-166. [Pg.854]

Because the main limitation of the stoichiometric bioscavenger approach is the cost of the huge dose of enzyme to be administered for challenging the OP molecules, a way to circumvent this problem is to in vivo reactivate the administered enzyme, turning the stoichiometric bioscavenger into a pseudocatalytic bioscavenger. [Pg.1109]

See other pages where Stoichiometric bioscavengers is mentioned: [Pg.85]    [Pg.701]    [Pg.701]    [Pg.705]    [Pg.979]    [Pg.1027]    [Pg.1027]    [Pg.1047]    [Pg.1053]    [Pg.1054]    [Pg.40]    [Pg.43]    [Pg.50]    [Pg.58]    [Pg.145]    [Pg.147]    [Pg.155]    [Pg.156]    [Pg.156]    [Pg.157]    [Pg.175]    [Pg.178]    [Pg.178]    [Pg.185]    [Pg.185]    [Pg.193]    [Pg.738]    [Pg.229]    [Pg.230]    [Pg.235]    [Pg.239]    [Pg.247]    [Pg.407]    [Pg.126]    [Pg.773]    [Pg.773]    [Pg.981]    [Pg.1094]    [Pg.1094]    [Pg.1108]    [Pg.1109]    [Pg.1109]    [Pg.1109]   
See also in sourсe #XX -- [ Pg.701 , Pg.702 , Pg.703 , Pg.704 , Pg.892 , Pg.978 , Pg.1016 , Pg.1027 , Pg.1041 , Pg.1053 ]



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Bioscavengers

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