Bioscavengers sources

Bioscavenger Source Species Substrate Specificity km (p.M) Vmax (nmol min mg ) Ref. 

All recombinant as well as monomeric forms of native esterases tested so far have a relatively low mean residence time in the circulation of mice. " Therefore, in their present form they are not suitable as scavengers of OP. This is discussed in detail later in the chapter. In general, only the tetrameric forms of plasma-derived ChE appear to have relatively long residence times in animals. Enzymes isolated from animal species or from plant or bacterial sources may not be suitable for use in humans, for they will cause adverse immune reaction. At the present time, HuBChE appears to be the most suitable bioscavenger enzyme for human use. Notably, the stabihty of exogenously administered HuBChE was determined in individuals identified as... 

Geyer, B.C., Kannan, L., Cherni, I., et al., 2010. Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase. Plant Biotechnol. 

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