Bioreceptor

C and T E Klein 1986. Molecular Graphics and QSAR in the Study of Enzyme-Ligand ractions. On the Definition of Bioreceptors. A ccounts of Chemical Research 19 392-400,... 

SENSORS BASED ON FREE-STANDING MOLECULARLY IMPRINTED POLYMER MEMBRANES. COMPUTATIONAL MODELLING OF SYNTHETIC MIMICKS OF BIORECEPTORS... 

Biosensors play a significant role in the monitoring of a wide range of diseases and pathogens. A biosensor is an analytical device, which incorporates a biological recognition element or bioreceptor which is capable of sensing the presence. 

The potential use of SERS in biodiagnostic tests has been demonstrated through the use of immobilized monolayers of bioreceptors, including oligonucleotides and antibodies. The use of surface-enhanced Raman gene... 

Brynda E., Houska M., Skvor J., Ramsden J.J., Immobilisation of multilayer bioreceptor assemblies on solid substrates. Biosens, Bioelectron. 1998 13 165-172. 

Hansch, C. and Klein, T.E. (1986) Molecular graphics and QSAR in the study of enzyme-ligand interactions. On the definition of bioreceptors. Accounts of Chemical Research, 19, 392-400. 

Bioreceptors Antibodies Lectins Cell membrane receptors Nucleic acids Synthetic molecules... 

J. S. Schultz, Design of fibre-optic biosensors based on bioreceptors, in Biosensors Fundamentals andApplications (A. P. F. Turner, I. Karobe, and G. S. Wilson, eds.), Oxford University Press, New York (1987). 

The analytical device is represented by an amperometric biosensor able to monitor the evolution of photosynthetic 02, obtained by coupling a suited algal bioreceptor to a Clark electrode. The selected algal species is the marine filamentous cyanobacterium Spirulina subsalsa (Campanella [4]). Further details on the application of biosensors for integral toxicity... 

In a typical configuration of a DNA biosensor, the bioreceptor is an ssDNA called the capture probe that is immobilised by one of the methods described above. The analyte, a complementary ssDNA called... 

Adrian, J., D.G. Pinacho, B. Granier, et al. 2008. A multianalyte ELISA for immunochemical screening of sulfonamide, fluoroquinolone and 13-lactam antibiotics in milk samples using class-selective bioreceptors. Anal. Bioanal. Chem. 391 1703-1712. 

Jiang P, Guo Z. Fluorescent detection of zinc in biological systems recent development on the design of chemosensors and bioreceptors. Coord Chem Rev 2004 248 205-29. 

A different approach has been the coupling of microdialysis with biosensing techniques. These latter are non-separation techniques based on molecular recognition of the target analjde, which may form a complex with a bioreceptor, allowing its selective identification even in a complex mixture. 

The reaction between the analjrte and the bioreceptor produces a physical or chemical output signal normally relayed to a transducer, which then generally converts it into an electrical signal, providing quantitative information of analytical interest. The transducers can be classified based on the technique utilized for measurement, being optical (absorption, luminescence, surface plasmon resonance), electrochemical, calorimetric, or mass sensitive measurements (microbalance, surface acoustic wave), etc. If the molecular recognition system and the physicochemical transducer are in direct spatial contact, the system can be defined as a biosensor [76]. A number of books have been published on this subject and they provide details concerning definitions, properties, and construction of these devices [77-82]. 

Easy electrochemical control of the surface single step suitable for the fabrication of micro sensors control and orientation of biomolecules Simple many biocompatible pol5miers available suitable for a large variety of bioreceptors Reusable surface... 

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