Bioprocess modeling

Heinzle, E., Biwer, A. P. and Cooney C. L. (2007) Development of Sustainable Bioprocesses - Modelling and Assessment, Wiley. 

Liibbert, A., and Simutis, R. (1994). Using measurement data in bioprocess modelling and control. Trends Biotechnol. 12, 304-311. 

Freitas S S, Santos J A L, Prazeres D M F (2006) Plasmid DNA production. In E Heinzle, A Biwer, C Cooney (eds.), Development of Sustainable Bioprocesses Modeling and Assessment. Wiley, New York, pp. 271-285. 

Roeva, O., Trenkova, T. Genetic algorithms and firefly algorithms for non-linear bioprocess model parameters identification. In Proceedings of the 4th International Joint Conference on Computational InteUigence (ECTA), Barcelona, Spain, 5-7 October 2012, pp. 164-169 (2012)... 

Bioprocesses, Modelling and Assessment, John Wiley Sons, Inc., New York. 

Simple bioprocess models are typically based on batch fermentation processes where the change in cell concentration with respect to time is proportional to the current cell concentration. This first-order rate equation is mathematically described by... 

Bellgardt, K.-H. (2000a), Bioprocess models, in Bioreaction Engineering Modeling and Control, K. Schugerl, and K.-H. Bellgardt, Editors, Berlin, Springer 44-105. 

Aerobic fermentation of P.polymyxa in medium containing 3% corn meal, 3% glucose, and yeast extract yielded polymyxin at very good concentration.Rangaswamy et al. proposed a bioprocess model for lai e-scale production of polymyxin from oatmeal-based medium and purification of polymyxin. Figure 14.11 shows their downstream process. ... 

Heinzle, Elmar, Arno P. Biwer, and Charles L. Cooney. Development of Sustainable Bioprocesses Modeling and Assessment. Hoboken, N.J. John Wiley Sons, 2007. Looks at making bioprocesses sustainable by improving them. Includes case studies on citric acid, biopolymers, antibiotics, and biopharmaceuticals. Nebel, Bernard J., and Richard T. Wright. Environmental Science Towards a Sustainable Future. 10 th ed. Englewood Cliffs Prentice Hall, 2008. Describes several bioprocesses used in waste treatment and pollution control. 

Hybrid modelling has been recognised as a valuable methodology for increasing the benefit/cost ratio of bioprocess modelling (Schubert et al. (1994), Preusting et al. 

Heinzle E, Biwer AP, Cooney CL (2007) Development of sustainable bioprocesses modelling and... 

J. B. Snape, in Dynamics of Environmental Bioprocess Modelling and Simulation, Weinhein, New York, 1995. 

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