Biopharmaceuticals future research issues

Thus far, no national standards laboratory (e.g., NIST) or private standards organization has issued, or recommended, suitable proteins for use in an HX-MS calibration hierarchy. This absence is not surprising, as investigators using HX-MS have yet to settle on a set of consensus standard RM. In view of the rapid expansion in the use of HX-MS for research applications and its likely future applications as a quality control for biopharmaceuticals, perhaps it is time for the HX-MS community, the national standards laboratories, and RM producers to devote resources to identifying and characterizing proteins that can serve as suitable reference proteins. 

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