Biopharmaceuticals chloroplasts

Chloroplast Derived Antibodies, Biopharmaceuticals and Edible Vaccines... 

Chloroplast-derived Biopharmaceuticals 8.3.2.1 Human Serum Albumin... 

Chloroplast Derived Antibodies, Biopharmaceuticals and Edible Vaccines 8.3.3.3 Yersinia pestis Fl-V Fusion Antigen... 

Since plastids have a limited set of protein degradation pathways, foreign proteins that exhibit harmful effects to the plant in the cytoplasm may be more stable when they accumulate within the chloroplast (Heifetz, 2000). For example, the vaccine protein cholera toxin B subunit was shown to be toxic even when it accumulated to very low levels within the plant cytoplasm, but was nontoxic when it accumulated to large quantities within the chloroplast. Plastids also possess the ability to form disulfide bonds, a requirement for many correctly folded mammalian proteins (Daniell et al., 2005a). These properties have made them attractive for the production of biopharmaceuticals in plants. 

Chebolu, S. and Daniell, H. (2009). Chloroplast-derived vaccine antigens and biopharmaceuticals expression, folding, assembly, and functionality. Curr. 

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