Biopharmaceutical considerations

Kaplan, S. A., Biopharmaceutical considerations in drug formulation and design and evaluation, Drug Metab. Rev. 1972, 1, 15-34. 

Ballard, B.E. (1968). Biopharmaceutical considerations in subcutaneous and intramuscular drug administration. J. Pharm. Sci 57 357-378. 

Davies, N.M. 2000. Biopharmaceutical considerations in topical ocular drug delivery. Clin Exp Pharm Phys 27 558. 

Until recently, nonparenteral routes have failed to deliver sufficient quantities of ASO to be systemically therapeutic. The recent advent of novel oral delivery technologies, coupled with the increased tissue residence time for second-generation ASOs, allows oral delivery to achieve therapeutic levels for select systemic indications. This chapter will initially outline certain more conventional aspects of parenteral dosage forms, and then focus on formulation technologies that more specifically address local treatment. For the oral route, we will pass to the biopharmaceutic considerations for both local delivery to the gut and systemic delivery via absorption from solid dosage forms. Incumbent with the discussion on formulations is the need initially to overview the physico-chemical properties of ASOs, which in large part determine their biopharmaceutic characteristics. 

Antiepileptic Drug Formulation and Treatment in the Elderly Biopharmaceutical Considerations... 

Table 1 Biopharmaceutic considerations in drug product design...

Biopharmaceutic considerations in the design and manufacture of a drug product to deliver the active drug with the desired bioavailability characteristics include 1) the type of drug product (e.g., solution, suspension suppository) 2) the nature of the excipients in the drug product 3) the physicochemical properties of the drug molecule and 4) the route of drug administration. 

Crommelin D. Formulation of biotech products, including biopharmaceutical considerations. In Crommelin, DJA, Sindelar RD, eds. Pharmaceutical Biotechnology An Introduction for Pharmacists and Pharmaceutical Scientists. Amsterdam Harwood Academic Publishers, 1997 71-99. 

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