Biomimetic simulated body fluid

H.Y. (2006) Carbon nanotubes assisted biomimetic synthesis of hydroxyapatite from simulated body fluid. Mater. Sci. Eng. A, 426, 202-207. 

Metastable synthetic (or modified) simulated body fluids (SBFs), with an inorganic salt composition similar to that of human blood plasma, incubate and faciUtate the spontaneous nucleation and growth of nanosized, carbonated and bone-like apatite at physiological pH and temperature. SBFs were first used by Kokubo andTakadama (52) in biomimetic synthesis to prove the similarity between the in vitro and in vivo behaviors of certain glass-ceramic compositions. Some typical SBF compositions are listed in Table 12.1. In these studies, the glass-ceramic samples were soaked in SBF solutions and their surfaces coated with a poorly crystallized calcium-deficient and carbonatebone apatite. A metastable SBF has been proven to incubate and facilitate the... 

Azami M, Moosavifar MJ, Baheiraei N, Moztarzadeh F, Ai J. Preparation of a biomimetic nanocomposite scaffold for bone tissue engineering via mineralization of gelatin hydrogel and study of mineral transformation in simulated body fluid. J Biomed Mater Res A 2012 100(5) 1347-55. 

Hofmann et al. [55] have created a bioactive cellulose surface where the nonwo-ven cellulose (regenerated, oxidized) fabrics were coated with hydroxy-carbonated apatite, using a procedure based on a biomimetic method (Figure 14.8). A simulated body fluid with a high degree of supersaturation was appHed to accelerate the biomimetic formation of boneUke apatite on the cellulose fabrics. These materials are under consideration as attractive candidates for scaffolds in bone tissue engineering. 

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