Biomimetic methodology

Ehlers GAC, Loibner AP (2006) Linking organic pollutant (bio)availability with geosorbent properties and biomimetic methodology A review of geosorbent characterization, and (bio)availability prediction. Environ Pollut 141 494-512... 

Kelly s biomimetic methodology, first reported in 2003 (03AG(E)83), has become one of the most reliable routes to thiazolines. In this approach, the phosphorus-activated amide carbonyl group undergoes nucleophilic... 

Hydrogen bonding is recognized, among the many biomimetic methodologies, as the only motif that meets the criteria of high... 

Reproduced from Lima, A.C., et al., 2013. Biomimetic methodology to produce polymeric multilayered particles for biotechnological and biomedical applications. Small, 9 (15), 2487-2492, with permission of John Wiley and Sons (http //onlinelibrary.wiley.com/ joumal/10.1002/(ISSN)1613-6829). 

Johnson, W. S. Shenvi, A. B. Boots, S. G. An approach to taxodione involving biomimetic polyene cyclization methodology. Tetrahedron 1982, 38, 1397-1404. 

This methodology was applied to biomimetic diversity-oriented synthesis to discover galanthamine-like molecules (153) with biological properties beyond those of the natural product by Shair and co-workers [114] (Scheme 24). 

Thus, although the yields in the oxidative cyclizations of diphenolic substances and their derivatives may sometimes be lower than might be desired, this biomimetic approach constitutes a rapid and concise entry to the crinine family of alkaloids. Continued research in this area should lead to the development of improved synthetic methodology and tactics for effecting this important conversion, resulting thereby in highly useful syntheses of members of this class of naturally occurring bases. 

The hydroxyl groups encircling the bucket rims also offer sites for the attachment of a reporter site. Most synthetic methodologies for site derivatization have been developed in studies aimed at promoting biomimetic transformations of substrates included within the CD cavity [144-146], Notwithstanding, these... 

In Chap. 6, biological supermolecules are explained and classified by function. Artificial supramolecular systems that mimic biological ones are also described. Biomimetic chemistry, which mimics the essence of a biosystem and then develops an artificial system that is better than the biological one, is widely used in this field. Fimctional developments, such as molecular transport, information transmission and conversion, energy conversion and molecular conversion (enzymatic functionaUty) based on biomimetic chemistry are described. New methodologies such as combinatorial chemistry and in vitro selection mimic evolutionary processes in nature. We leave this topic until the end of the book because we want to show that there is still lots to do in supramolecular chemistry, and that supramolecular chemistry has huge future potential. 

Methodologies for the fabrication of biomimetic membranes vary somewhat from one biomimetic membrane to another. However, a number of experimental procedures for the formation of lipid monolayers and bilayers on solid supports are common to several biomimetic membranes. The most popular procedures are vesicle fusion, Langmuir-Blodgett and Langmuir-Schaefer transfers, and rapid solvent exchange. The formation of lipid monolayers and bilayers on gold and... 

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