Biomedical Applications of PLA Stereo-complex

PLLA/PDLA Stereo-complex allows enhancing the thermal-resistance and mechanical properties as well as the hydrolytic stability of PLA-based materials. In the past decades, a great deal of work has been performed to exploit potential biomedical applications of PLA stereo-complex as shown in Table 2.1. [Pg.47]

Stereo-complex films were reported by Masutani et al7 % combining bifunctional PLLA and PDLA pre-polymers, multi-stereo-block copolymers having different block lengths and sequences are obtained. The resultant copolymers are readily fabricated into transparent films by hot-pressing. The films present excellent thermal stability and thermo-mechanical properties because of the easy formation of stereo-complex crystals. This synthetic method based on tbe dual terminal couplings allows obtaining stereo-block copolymers of PLLA and PDLA showing excellent thermo-mechanical properties and melt processability. [Pg.47]

Watanabe et al. reported stereo-complex material by enantiomeric PLA graft-type phospholipid copolymers as tissue engineering scaffolds. The copolymers as cell-compatible materials are prepared using a phospholipid copolymer composed of 2-methactyloyloxyethyl phosphotylcholine, n-butyl methacrylate, and enantiomeric PLLA and PDLA macromonomers. The porous scaffold presents advantages for tissue engineering, including cell compatibility using phospholipid copolymer, adequate cell adhesion by PLA [Pg.47]

PLLA/PDLA Nanofibre 400-1400 nm Tissue engineering Tsuji et al. [Pg.48]

PLLA/PDLA Porous scaffold 200 im Tissue engineering Watanabe et alJ ° [Pg.48]