Biomedical applications blood oxygen

Biomedical Applications Due to their excellent blood compatibility (low interaction with plasma proteins) and high oxygen and moisture permeabilities, siloxane containing copolymers and networks have been extensively evaluated and used in the construction of blood contacting devices and contact lenses 376). Depending on the actual use, the desired mechanical properties of these materials are usually achieved by careful design and selection of the organic component in the copolymers. 

Polysiloxane based block copolymers have also been examined with respect to their transport properties, because these copolymers are of special interest as membranes in various biomedical applications 376). The combination of good mechanical, dielectric, permeation and film formation properties of siloxane-carbonate segmented copolymers have led to their use as blood oxygenation, dialysis and microelectrode membranes 392 394. ... 

A recent study with biotechnology applications relates to amino acid extraction. Schugerl and co-workers (71 ) used a quaternary ammonium carrier in an emulsion liquid membrane system for enzyme catalyzed preparation of L-amino acids. Frankenfield et al. (72) discuss a wide variety of biomedical ELM applications including enzyme encapsulation, blood oxygenation, and treatment of chronic uremia. 

An example of gas permeation in a membrane is use of a polymeric membrane as an oxygenator for a heart-lung machine to oxygenate blood. In this biomedical application, pure O2 gas is on one side of a thin membrane and blood is on the other side. Oxygen diffuses through the membrane into the blood and CO2 diffuses in a reverse direction into the gas stream. 

Biomedical materials include metals, ceramics, natural polymers (biopolymers), and synthetic polymers of simple or complex chemical and/or physical structure. This volume addresses, to a large measure, fundamental research on phenomena related to the use of synthetic polymers as blood-compatible biomaterials. Relevant research stems from major efforts to investigate clotting phenomena related to the response of blood in contact with polymeric surfaces, and to develop systems with nonthrombogenic behavior in short- and long-term applications. These systems can be used as implants or replacements, and they include artificial hearts, lung oxygenators, hemodialysis systems, artificial blood vessels, artificial pancreas, catheters, etc. 

Bamford, C.H. and AI-Lamee, K.G. 1996. Studies in polymer surface modification and grafting for biomedical uses 2. Application to arterial blood filters and oxygenators. Polymer. 37 4885-4889. 

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