Biomedical applications blood glucose

NIR spectral measurements of human skin stretch back to 1950s. Real trials for in vivo and in vitro NIR spectroscopic determination of biomedical components with chemometrics started in 1980s. There have been two major streams for NIR-chemometrics investigations on biomedical components. One is concerned with the quantitative analysis of various biomedical analytes in in vitro samples, especially in human serum, and the other is in vivo blood glucose measurement for possible application to clinical diagnosis. 

Lack of biocompatibility [39] was mentioned but seems to be now reconsidered there is few applications in biomedical domain. The main applications are in food [40] as a thickener or stabilizer of emulsions. They are also used in personnal care, cosmetic and pharmaceutic compositions and household care products for which there are many patents [37, 41,42]. Low molecular weight sulphated derivatives of galactomannan have anticoagulant activity[28]. Different pharmaceutical applications are mentioned in the literature as example for blood glucose-lowering effect[43], or to produce tablets by compression and control the release of drugs [44-46]... 

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