Biology Oriented Synthesis application

Mamane, V., Garcia, A. B., Umarye, J. D., Lessmann, X, Sommer, S., Waldmann, H. Stereoselective allylation of aldehydes on solid support and its application in biology-oriented synthesis (BIOS). Tetrahedron 2007,63,5754-5767. 

In this chapter, we address two complimentary approaches to componnd collection development namely, Diversity Oriented Synthesis (DOS) and Biology Oriented Synthesis (BIOS). For additional, very well-validated approaches snch as fragment-based design and the application of in silico methods to develop compound libraries the reader is referred to different chapters in this book and to authoritative reviews. " ... 

Modem acetylene chemistry plays a critical role in the current world-wide efforts to synthesize new molecular and polymeric carbon allotropes as well as carbon-rich nanomaterials. It is rapidly becoming clear that the preparative challenges in this interdisciplinary research area at the interface between materials science and chemistry are formidable and rival those in the more established synthesis of natural products and biologically active compounds. Modern materials research strongly relies on advanced synthetic methodology, and it is hoped that the field will attract many synthetically oriented chemists into its ranks their efforts will be rewarded by the development of materials with unique properties and unprecedented applications. 

Application in Total Synthesis. Based on a Michael-oriented 6-endo-trig cyclization, Corey has reported stereocontrolled syntheses of salinosporatnide A and biologically active analogs... 

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