Biologically active macromolecules advantages

All applications mentioned above can be done on an analytical or preparative scale depending on the size of the column used. In preparative applications, the great advantage of GPC over many other analytical methods should be stressed, namely the fact that the conditions of analysis in no way affect the structure or any other property of the macromolecules. By contrast, GPC may be carried out in whatever environment is most suitable for the test substance. As a consequence the method not only allows an analysis of the biological material but also preserves its biological activity, so that the fractions can be subjected to further study of their biological properties. 

To improve the mechanical and biological properties of chitosan, natural macromolecules like gelatin have been extensively used due to their inherent advantages such as biocompatibility and biodegradability [2, 15]. Gelatin contains Arg-Gly-Asp (RGD)-like sequence that promotes cell adhesion and migration, and also forms a polyelectrolyte complex, that is the reason why it can improve the biological activity of chitosan [2]. 

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