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Biological target, identifying

Medicinal chemists have a distinct advantage in pursuing mechanism-of-action studies because it is possible to synthesize a series of structurally related congeners and measure their biological activity. A correlation between activity and particular structural features not only helps to identify the pharmacophore, or active moiety imbedded within the molecule, but also may establish critical requirements or complementarity for the biological target or receptor for the particular drug class. [Pg.13]

The initial screen applied to assess the activity of a collection of compounds against a biological target of interest. This SCREEN identifies ACTIVES from a LIBRARY. [Pg.79]

In this section, we present some recent applications of DFT to the study of enzymatic reactions of pharmaceutical interest. One of the major aims of these studies was to identify TS features that, because the biological targets investigated are involved in the pathogenesis of diseases, could be exploited when designing inhibitors of these enzymes. [Pg.58]

Most, if not all, pharmaceutical companies are now identifying the genetic variability around the targets for their molecules. This is absolutely critical to be sure that the chemical molecule binds to the most common form of the biological target and not a rare form or a form found only in animals. [Pg.94]

The area of greatest potential, but also greatest risk, is when there is a condition for which a biological target has been identified, but no proven product has yet been developed for it. [Pg.343]

Much research has been invested to identify a common and validated test method that may be used in all industrial laboratories concerned by phototoxicology. Cultured mammalian cells constitute an essential model for the evaluation of phototoxicity. Such systems include all biological targets (lipids in membranes, proteins, nucleic acids) as well as active pathways likely to modulate the phototoxic impact (apoptotic pathways, cellular defenses, endogenous antioxidants, repair pathways, metabolism). [Pg.482]


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See also in sourсe #XX -- [ Pg.86 ]




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Biological targets

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