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Synthesis biological structure

Lomant, A.J., and Fairbanks, G. (1976) Chemical probes of extended biological structures synthesis and properties of the cleavable cross-linking reagent [35S] dithiobis(succinimidyl propionate)./. Mol. Biol. 104, 243-261. [Pg.1089]

Each section has the following structure synthesis of target structures, properties including spectral properties (meaning anomalous or confirming structure), reactions on ring atoms, reactions on substituents, partially saturated heterocycles, applications, and biological properties. [Pg.192]

The steroid ring structure is complex and contains many chiral carbons (for example at positions 5, 8, 9,10,13,14 and 17) thus many optical isomers are possible. (The actual number of optical isomers is given by 2" where n = the number of chiral carbons). From your knowledge of biochemistry you should have realised that only one of these optical isomers is likely to be biologically active. Synthesis of such a complex chemical structure to produce a single isomeric form is extremely difficult, especially when it is realised that many chemical reactions lead to the formation of racemic mixtures. Thus, for complete chemical synthesis, we must anticipate that... [Pg.297]

NATURAL DITERPENE AND TRITERPENE QUINONE METHIDES STRUCTURES, SYNTHESIS, AND BIOLOGICAL POTENTIALS... [Pg.269]

Stuhrmann, H. B. Resonant X-Ray Scattering in Biological Structure Research, 145, 151-171 (1987). Suzuki, A. Some Aspects of Organic Synthesis Using Organoboranes. 112, 67-115 (1983). [Pg.252]

Enzymes catalyze metabolic reactions, the flow of genetic information, the synthesis of molecules that provide biological structure, and help defend us against infections and disease. [Pg.221]

The term biology-oriented synthesis (BIOS) [45] has been used to describe the design of compound libraries based on biologically relevant chemical space [46]. The areas in protein structures that participate in productive protein-ligand interactions have been, for the most part, already defined by natural products and drugs. Thus libraries inspired by natural products and other bioactive molecules are expected to have a higher probability of biologically activity than randomly synthesized molecules [47,48]. [Pg.415]

A naturally occurring phenazine of nonbacterial origin is the methano-phenazine (MP) (10) which has been isolated from the cytoplasmic membrane of Methanosarcina (Ms.) mazei Gol archaea. The structure, synthesis, properties, and function of this natural product will be discussed in detail since it is not only the first and so far the sole phenazine derivative from archaea, but also the first one that is acting as an electron carrier in a respiratory chain - a biologic function equivalent to that of ubiquinones in mitochondria and bacteria. [Pg.80]

ADME models Structural biology Parallel synthesis Medicinal chemistry... [Pg.335]

Pedras MSC, Zheng Q-A, Sarma-MamillapaUe VK (2007) The phytoalexins from Brassicaceae structure, biological activity, synthesis and biosynthesis. Nat Prod Commun 2 319-330... [Pg.137]

Anderson, L. Unger, F. M. Bacterial Lipopolvsaccharides Structure. Synthesis and Biological Activities. American Chemical Society Washington, DC 1983 ACS Symp. Ser. No. 231. [Pg.175]

Molinski, T. F. 1993. Marine pyridoacridines alkaloids Structure, synthesis, an biological chemistry. Chemical Reviews, 93 1825-1838. [Pg.262]

N. K. Kochetkov, in L. Anderson and F. M. Unger (Eds.), Synthesis of O-antigenic polysaccharides. Pathways for the polymerization of oligosaccharide repeating units, Bacterial Lipopolysaccharides Structure, Synthesis and Biological Activities, ACS Symp. Ser., Vol. 231, Amer. Chem. Soc., New York, 1983, pp. 65-81. [Pg.17]

Molinski, T. F., Marine pyridoacridine alkaloids structure, synthesis, and biological chemistry, Chem. Rev., 93, 1825, 1993. [Pg.29]

The structure, synthesis and biological activity of natural 2-oxetanones and their derivatives has been reviewed (95S729). The synthesis of some novel 3-(hydroxymethyl)-4-(2-substituted ethyl)-2-oxetanones and their biological activity as 3-hydroxy-3-methyl-glutaryl coenzyme-A inhibitors has been reported (94CPB1272, 94CPB2097). [Pg.71]

The structures, synthesis, and some of the biological properties of these three major classes of mycobacterial glycolipid antigens are the basis of this article. [Pg.179]

Structure, function and biochemistry of the cestode tegumentary membrane and associated glycocalyx. In Endocyto-biology. endosymbiosis and cell biology, a synthesis of recent research, ed. W. Schwemmler H. E. A. Schenk, pp. 587-603. Walter de Gruyter Berlin. [Pg.345]

Rossert J, de Crombrugghe B Type 1 collagen structure, synthesis, and regulation, in Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, CA, 2002,... [Pg.333]

Widespread Mabis (apple), Rosa (rose hip) (Rosaceae), Citrus (Rutaceae), Capsicum (Szegedi paprika) (Solanaceae) spp. Vitamin C reaches 20-300 mM in chloroplasts discovered by Albert Szent-Gyorgyi (Hungary/ USA, Nobel Prize, 1937 [vitamin C biological oxidations]) structure synthesis (Sir Walter Haworth (UK, Nobel Prize, Chemistry, 1937, [carbohydrates vitamin C]) identified by W.A. Waugh C.G. King (USA)... [Pg.631]

Wengler, G. (1980). Effects of alphaviruses on host cell macromolecular synthesis. In The Togaviruses Biology, Structure, Replication (R. W. Schlesinger, Ed.), pp. 459-472. Academic Press, New York. [Pg.377]

Narquizian R, Kocienski PJ. The pederin family of antitumor agents structures, synthesis and biological activity. In The Role of Natural Products in Drug Discovery, Vol. 32. Mulzer R, Bohlmann R, eds. 2000. Springer, Heidelberg, Germany, pp. 25-56. [Pg.1756]

Jann K (1983) Exopolysaccharides of E. Coli. In Anderson L, Unger FM (eds) Bacterial Polysaccharides Structure, Synthesis, and Biological Activities. ACS, Washington, DC, p 171... [Pg.49]


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See also in sourсe #XX -- [ Pg.76 , Pg.77 , Pg.78 , Pg.79 , Pg.80 , Pg.81 , Pg.82 , Pg.83 , Pg.84 , Pg.85 , Pg.86 , Pg.87 , Pg.88 , Pg.89 ]




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