Biological rationale

The signaling molecules downstream of NgR or the GTlb/p75 complex, which transduce the intracellular activation signals of Nogo-A, MAG and OMpg, are largely unknown. Experimental 

In summary, NgR is a key receptor involved in blocking neurite growth. By interfering with its action, either directly by inhibiting the receptor/ligand interactions or indirectly by interfering with the signal transduction cascade, it may be possible to develop new therapeutic treatments for neuronal injuries. 

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As has been clearly demonstrated, pi05 has two distinct ubiquitin system targeting motifs, an acidic domain that contains also the Lys residues essential for ubiquitin anchoring, and a C-terminal phosphorylation/E3-binding domain. An important, yet unresolved, question involves the biological rationale behind the evolution of these two sites. To resolve this... 

Fig. 1. Targeted clinical trial design for evaluating a new experimental therapy. A biomarker classifier is developed for identifying those patients most likely to respond to the new treatment (E). Only those patients are randomized to E versus the control treatment. The patients predicted less likely to respond (marker negative) are off-study. The targeted design is most useful in cases where the biomarker classifier has a strong biological rationale for identifying responsive patients and where it may not be ethically advisable to expose marker negative patients to the new treatment.

Prasad K. N., Cole W. C., Hovland A. R., Prasad K. C., Nahreini P., Kumar B., Edwards-Prasad J., and Andreatta C. P. (1999). Multiple antioxidants in the prevention and treatment of neurode-generative disease analysis of biologic rationale. Curr. Opin. Neurol. 12 761-770. 

Sabbah HN. Biologic rationale for the use of beta-blockers in the treatment of heart failure. Heart Fail Rev. 2004 9 91-97. 

The biological rationale for the production of siderophores by microorganisms is the irreplaceable role of iron in nearly all oxidation and reduction processes of cells, combined with the extreme insolubility of ferric hydroxide at physiological pH. At pH 7 the equilibrium concentration for ferric ion (as free [Fe3+]) is approximately... 

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