Biological polymers INDEX

In Volume 3, our Section Editors have assembled 12 contributions in six sections. Topics covered include Simulation Methodologies (Carlos Simmerling), Biological and Biophysical Applications (Heather Carlson), Chemical Education (Theresa Zielinski), Materials and Polymers (Jeffry Madura), Quantum Chemistry (T. Daniel Crawford), and Emerging Technologies (Wendy Cornell). With Volume 3, we extend the practice of cumulative indexing of both the current and past editions in order to provide easy identification of past reports and topics. 

Biological and clinical studies have underlined the fundamental importance of the polymer-drug linker. When a conjugate is administered parenterally its stability in the circulation and ability to release drug at an appropriate rate on arrival in the target tissue is a principal determinant of therapeutic index. A variety of chemistries can be used to create pendant linkers (Fig. 5) (10). Lysosomally degradable peptides ensure site-specific intracellular activation, but many drug candidates do not have a convenient aliphatic -NH2 for this purpose. 

Contact lenses are the most common polymer product in ophthalmology. The basic requirements for this type of materials are (T)excellent optical properties with a refractive index similar to cornea good wettability and oxygen permeability ( ) biologically inert, degradation resistant and not chemically reactive to the transfer area ( ) with certain mechanical strength for intensive processing and stain and precipitation prevention. The common used contact lens material includes poly-P-hydroxy ethyl methacrylate, poly-P-hydroxy ethyl methacrylate-N-vinyl pyrrolidone, poly-P-hydroxy ethyl methacrylate, Poly-P-hydroxy ethyl methacrylate - methyl amyl acrylate and polymethyl methacrylate ester-N-vinyl pyrrolidone, etc. The artificial cornea can be prepared by silicon rubber, poly methyl... 

Contents J. M. BRAND, J. CHR. YOUNG, and R. M. SILVERSTEIN, Insect Pheromones A Critical Review of Recent Advances in Their Chemistry, Biology, and Application - M. McNEIL, A. G. DARVILL, and P. ALBERSHEIM, The Structural Polymers of the Primary Cell Walls of Dicots - U. SCHMIDT, J. HAUSLER, ELISABETH OHLER, and H. POISEL, Dehydroamino Acids, a-Hydroxy-a-amino Acids and a-Mercapto-a-amino Acids — Author Index — Subject Index. 

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