Biological Localization

The turnover time of intact Lb is relatively short [reviewed in (37)], cf. the long half-lives of myoglobin and hemoglobin in mammals, with the major Lb components of pea nodules having turnover times of about two days (49). This is considerably less than the lifetime of the nitrogenase (50). There must therefore be continual synthesis and degradation of Lb within the host cell cytoplasm, and there is evidence for dramatic changes (as mentioned earlier) in relative concen- 

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Bucka SM, Xua H, Brasuel M, Philbert MA, Kopelman R (2004) Nanoscale probes encapsulated by biologically localized embedding (PEBBLEs) for ion sensing and imaging in live cells. Talanta 63 41-59... 

PEBBLE probe encapsulated by biologically localized embedding... 

Buck SM Koo YEL Park E Xu H Philbert MA Brasubl MA Kopelman R, Optochemical nanosensor PEBBLEs Photonic explorers for bioanalysis with biologically localized embedding, Curr. Opin. Chem. Biol., 2004, 8, 540-546. 

C. A. Floudas and P. M. Pardalso, Optimization in Computational Chemistry and Molecular Biology Local and Global Approaches, Kluwer Academic, Dordrecht, 2000. 

Biology Locally abundant in certain parts of Canada but poorly known very little published information. 

A related technology called PEBBLES (Probes Encapsulated by Biological Localize) has been applied to deliver dye-tagged particles into living cells to monitor drug metabolism or changing disease conditions [48] (see also Part V, Chapters 4 and 5). The sensor is oxygen sensitive and can be used to monitor live cells. 

Biological Localization Reactions with Different Molecules... 

PEBBLE Photonic explorers for bioanalyse with biologically localized... 

M. G. lerapetritou, 1. P. Androulakis, D. S. Monos, and C. A. Floudas, Structure prediction of binding sites of MHC Class 11 molecules based on the crystal of HLA RBl and global optimization, in Optimization in Computational Chemistry and Molecular Biology Local and Global Approaches, Kluwer Academic Publishers, Hingham, MA, 2000, pp. 157-189. 

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