Biological functional properties scaffolds

The multiscale system also appears to be capable of providing more enhanced biological functionality, particularly for vascularization, which is favored by the interaction of ECs with the nanofibrous network.s that allow suitable cell architecture and orientation for microtubule formation. Thus, the synergistic effect of micro- and nanoscales could successfully regenerate natural tissues in vivo in the near future. Future work should focus on optimizing this process to better recapitulate key features of the native ECM, including its mechanical and biochemical properties, which would enhance the functionality of these 3D multiscale scaffolds in order to fabricate functional tissue engineered constructs. 

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