Biological concepts bacteria

Thus Ehrlich s original concept that dyes having a high infinity for bacteria could be modified structurally to make them bactericidal set off a series of chemical and biological events which resulted in heavy inroads into some major disease categories. A testable theory thus resulted in new biological information which led to a second testable theory. 

In this chapter, the molecular-biological mode of action of macrolide antibiotics and the biochemical and genetic mechanisms of resistance to MLS antibiotics are reviewed. Based on a recent X-ray crystallographic study on a 50S ribosomal subunit from Haloarcula marismortui and the finding of intracellular macrolide accumulation, the mode of action from the viewpoint of a new hypothetical concept, deposition binding, and mechanisms of drug resistance in clinically isolated bacteria are discussed. In addition, recent major developments in macrolide antibiotics are briefly described. 

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