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The relatively small size of LHRH, Gln-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, provided an attractive target for medicinal chemistry to modify the natural peptide sequence providing analogues with enhanced physiological properties. A further powerful impetus for the synthesis of highly potent agonists was the relatively short in vivo half-life of the natural peptide. [Pg.154]

Zoladex is a trade mark, property of Imperial Chemical Industries PLC. [Pg.154]

See other pages where Biological activity of LHRH analogues is mentioned: [Pg.154]