Biological Activity and p53 Status

A highly relevant area of research interest is the p53 gene status of human tumors. The p53 protein is recognized as an important cell regulatory element necessary for cell cycle arrest and apoptosis induction. Wild type p53 function 

Relative resistance. 3 (1 NSCLC, 1 gastric, 1 7 (2 SCLC, 2 NSCLC, 2 

Sensitivity, TWI 70% 15(3 SCLC, 5 NSCLC, 5 Ovarian, 1 gastric, bladder) 2 (1 ovarian, 1 SCLC) 

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