Bioinorganic chemistry future

Bioinorganic chemistry will surely develop in an even wider area than it has thus far. Attention is likely to increase for studies on nonmetals, such as Se and As and their roles in, e.g., detoxification reactions. In addition, studies on elements such as aluminum (a possible causative factor in dialysis dementia and related to Alzheimer disease, senile dementia) and other abundant earth crust metals will increase. The role of bioinorganic catalysis to make and keep our environment clean has been mentioned in many of the previous chapters. It is to be expected that future catalytic processes, based on and derived from biological ones, will be as clean as possible, producing useful, harmless, and biodegradable products for the world. 

No doubt, we are only at the brink of this process. Thus, it is with the intention of linking coordination chemistry and biochemistry in their widest sense that the Metal Ions in Biological Systems series reflects the growing field of bioinorganic chemistry . We hope, also, that this series will help to break down the barriers between the historically separate spheres of chemistry, biochemistry, biology, medicine, and physics, with the expectation that a good deal of future outstanding discoveries will be made in the interdisciplinary areas of science. 

The rapid inerease in eomputer power coupled with the development of ever-more sophisticated DFT methods will, perhaps paradoxieally, provide computational routes to the development of improved MM parameters whieh will eventually filter down into widely available eomputer paekages. There is a eontinuing bright future for the applieation of moleeular meehanies/ dynamies to ever more eomplex problems in coordination and bioinorganic chemistry. 

S.H. van Rijt and P.J. Sadler (2009) Drug Discov. Today, vol. 14, p. 1089 - Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs . 

More than half of all enzymes have metal ions in their structure these are metalloenzymes. In most cases, the metals are essential to the action of the enzyme and are often at the active site where the substrate for the biochemical reaction is bound. All organisms require certain trace elements for growth. Some of these trace elements are the metal ions that the organism incorporates into its metalloenzymes. Of the inorganic elements, the following have been found to be essential for some species of plant or animal Mg, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, B, Si, Se, F, Br( ), and I. New elements are added to the list from time to time—titanium is a potential future candidate for inclusion, for example. In addition, Na, K, Ca, phosphate, sulfate, and chloride are required in bulk rather than trace amounts. Metal ions also play an important role in nucleic acid chemistry. The biochemistry of these elements is termed bioinorganic chemistry. ... 

The majority of publications in the field of inorganic chemistry (about 2/3) are related to transition metal complexes. This includes organometallic chemistry, catalysis and bioinorganic chemistry. It may be expected that the future research in inorganic chemistry will be intensively pursued in these fields. 

The objectives of the Metals in Medicine Program Announcement (PA-01-071 now reissued as PA-05-001) are i) identification of new targets for drug discovery ii) development of new in vitro and in vivo diagnostics iii) elucidation of new basic concepts that will enable future therapeutics development dnd iv) stimulation of collaborations between inorganic chemists and medical scientists to ultimately increase flie inqiact of bioinorganic chemistry research on health. 

It is the goal of this book to present in one place the key features, methods, tools, and techniques of physical inorganic chemistry, to provide examples where this chemistry has produced a major contribution to multidisciplinary efforts, and to point out the possibilities and opportunities for the future. Despite the enormous importance and use of the more standard methods and techniques, those are not included here because books and monographs have already been dedicated specifically to instrumental analysis and laboratory techniques. The 10 chapters in this book cover inorganic and bioinorganic spectroscopy (Solomon and Bell), Mossbauer spectroscopy (Miinck and Martinho), magnetochemical methods (Kogerler), cryoradiolysis (Denisov), absolute chiral structures (Riehl and Kaizaki), flash photolysis and studies of transients (Ferraudi), activation volumes (van Eldik and Hubbard), chemical kinetics (Bakac), heavy atom isotope effects (Roth), and computational studies in mechanistic transition metal chemistry (Harvey). 

Majumdar A (2014) Bioinorganic modeling chemistry of carbon monoxide dehydrogenases description of model complexes, current status and possible future scopes. Dalton Trans 43 (32) 12135-12145. doi 10.1039/c4dt00729h... 

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