Bioimaging analyzer

Fujino et al. described an interesting radio-TLC method for the analysis of paclitaxel and its 3-OH and 6-OH metabolites. After incubation of " C-paclitaxel with human liver microsomes, the supernatants were developed using a solvent system consisting of toluene-acetone-formic acid (60 39 1, v/v) and quantified with a bioimaging analyzer. The results obtained correlated well with those from RP-HPLC. 

Nagatsuka, S.-i., Ueda, K., Ninomiya, S.-i., and Esumi, Y. (1993). Application of bioimage analyzer on drug metabolism studies using thin layer chromatography. (I). Performance of the system coupled to an image analyzer. Yakubutsu Dotai 8 1261-1271. 

Figure 5 Schematic diagram of the principle of detection of the Bioimaging analyzer. (From Ref. 65.)...

Bacitracin, 462-463 Basic TLC, 3-4 Beer-Lambert law, 274,282 Betalains, 748-750 distribution, 748 practical experiments, 750 structure, 748 TLC of, 748-749 Biochemical studies, 343 Bioimaging analyzer, 354-355 Biological samples ... 

Bioimaging/Phosphor Imaging Analyzers (Fuji and Molecular Dynamics)... 

In general, as the newer range of detectors were brought onto the market they were very expensive in comparison to the linear analyzers. However, as competition and technological developments occur the prices are slowly coming down. A further consideration is that in the authors own institute, for example, one Bioimaging Analyser has replaced approximately ten linear analyzers. 

Rf values, 4,7,931-934 Radiation detectors, 349-355 bioimaging/phosphor imaging analyzers, 354-355,357... 

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