Biogenic amines agents

The answers are 321-cT 322-e, 323-i. (Hardman, pp 238-239, 791.) Reserpine is an adrenergic neuronal blocking agent that causes depletion of central and peripheral stores of NE and dopamine Reserpine acts by irreversibly inhibiting the magnesium-dependent ATP transport process that functions as a carrier for biogenic amines from the cytoplasm... 

The mechanism of action of neuroleptics is not sufficiently clear. However, it is believed that they are antagonists of dopamine and dopaminomimetics, and that their effect is connected in some way with the blockage of dopamine D receptors, which results in changes of behavioral reactions. Moreover, it is possible that they also block action on the serotonin receptors and M-choline receptors. It also is possible that antipsychotic agents disrupt the process of the release and return neuronal uptake of a number of biogenic amines. 

Conditions mimicking MDD can occur secondary to a wide variety of prescribed and illicit agents. With some drugs, the syndrome occurs as a direct and immediate effect. For example, some antihypertensive agents (e.g., reserpine, a-methyidopa) acutely antagonize central biogenic amine neurotransmitter systems. 

This phenomenon is one of the pillars of the biogenic amine hypothesis of depression (see Suicide later in this chapter). An intriguing finding with reserpine is that those susceptible to a depressive syndrome while on this agent also have an increased likelihood of a personal or family history of MDD, in comparison with those who are not susceptible. This finding suggests an interaction between a constitutional predisposition and the biochemical effects of this drug. Because depression is a... 

The fact that all of these agents, acting in different ways, both improved depression and increased the efficacy of norepinephrine and serotonin made practically irresistible the idea the depression was mediated (if not caused) by a decrease in the efficacy of one or both of the biogenic amine modulators. This idea was already prepared in the minds of scientists who had observed that resperine, a drug that depleted the brain of its biogenic amines, often precipitated depression. 

Eder, R., Brandes, W., and Paar, E. (2002a). Influence of grape rot and fining agents on the contents of biogenic amines in musts and wines. Mitt. Klosterneuburg 52, 204-217. 

UPS results are also available for the amino acids and their methyl esters, peptides, porphyrins, steroids, vitamins, opiate narcotics, biogenic amines, tranquilizers, antipyretic and antiinflammatory agents, quinonoid molecules (which are important for electron... 

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