Biodegradable polymers factors that influence

First, a brief overview of the degradation mechanism and the main factors that influence hydrolysis of bioresorbable polymers is provided. Then, the modeling approaches that can be used for characterizing the behavior of biodegradable devices will be summarized. 

The biocompatibility of a biomaterial is primarily related to its interaction with the innate immune system, ie, ultimately the inflammatory response that is induced. Factors that influence such response include physicochemical and stmctural properties of the surface and the total surface area of the material. For a biodegradable material, these properties change over time and for most polymers, the pH also decreases in the tissue adjacent to the material during degradation. Consequently, the biocompatibility of a biomaterial needs to be reassessed at different steps, because a degrading material no longer possesses the properties of the original, biocompatible material. 

The mechanical properties that are most often measured during biodegradable polymer degradation experiments are stiffness, strength, and elongation-at-break. These mechanical properties are influenced by a large number of factors, the most important... 

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