Biocompatibility enzymatic degradation

L. Cui, C. Tang, and C. Yin, Effects of quaternization and PEGylation on the biocompatibility, enzymatic degradability and antioxidant activity of chitosan derivatives. Carbohydrate Polymers, 87 (4), 2505-2511,2012. 

As the linkers for the modification of the side chains, the enzymatically degradable polypeptides, the pH-sensitive Schiff base, and glutathion-sensitive disulfide bonds are used, the process of which is described in detail below. Even though other kinds of polymers can be also used for the design of functional block copolymers, it is not easy to satisfy the low toxicity and biocompatibility requirements, and limited polymers are allowed for practical use. 

Its solutions are more resistant to bacterial and enzymatic degradation than many other organic thickeners Biocompatible... 

When a synthetic material is placed in the mouth, there are many concerns. Obviously the material must be biocompatible, with an appropriate host response (Wataha, 2001). Further, the material may be subjected to mechanical stresses (shock, fatigue and abrasion), and chemical and enzymatic degradation. Thus it is important that the material is manipulated in such a way as to obtain its optimum properties to withstand the long-term rigors imposed by the oral environment. In that regard, it is advantageous to have materials that are easier to manipulate, which in turn can promote a superior outcome. This is now being achieved in some cases by the development of injectable materials. 

Key words resorbable polymer, biocompatibility, hydrolytic degradation, enzymatic degradation, mechano-active tissue engineering, elastomeric properties, copolymerization, particulate leaching, gel spinning. 

Biocompatible microgels for the delivery of protein and DNA biomolecules were developed using acrylamide monomer, a bisacrylamide acetal crosslinker and potassium persulphate initiator. Encapsulation was shown to provide protection from enzymatic degradation of the protein or DNA. These particles demonstrated pH sensitivity such that in an acidic environment, as in the lysosome, the polymeric carrier degraded and released the encapsulated biomolecule. 9 refs. 

It was reported that some synthetic polymers are biocompatible and biodegradable, thus can be used as safe biomaterials in biomedical applications. Synthetic polymers are degraded hydrolytically unlike enzymatically degraded natural polymers. 

There are two major classes of natural polymers used as scaffolds polypeptides and polysaccharides (Table 37.1, Figure 37.1). Natural polymers are typically biocompatible and enzymatically biodegradable. The main advantage for using natural polymers is that they contain bio-functional molecules that aid the attachment, proliferation, and differentiation of cells. However, disadvantages of natural polymers do exist. Depending upon the application, the previously mentioned enzymatic degradation may inhibit... 

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