Biochip engineering

Center for Bioelectronics, Biosensors, and Biochips (C3B), Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, VA 23284-3038, USA guiseppi vcu.edu... 

Abraham, S., S. Brahim, K. Ishihara, and A. Guiseppi-Elie. 2005. Molecularly engineered p(HEMA)-based hydrogels for implant biochip biocompatibility. Biomaterials 26 4767. Bongiovanni, C., T. Ferri, A. Poscia, M. VaralK, R. Santucci, and A. Desideri. 2001. An electrochemical multienzymatic biosensor for determination of cholesterol. Bioelectrochemistry 54 17. 

Abraham, S., S. Brahim, K. Ishihara, and A. Guiseppi-Elie. 2005. Molecularly engineered p(HEMA)-based hydrogels for implant biochip biocompatibility. Biomaterials 26 4767. 

Biomaterials. Adsorbed polymers find many apphcations as surface modifiers in biomedical apphcations. By choosing a combination of hydrophobic and hydrophilic copolsrmers, surfaces can be modified to make them biocompatible (65) (see Biomolecules at Interfaces). In the area of tissue engineering (qv), adsorbed layers with specihc amino acid sequences can be used to promote cell adhesion and proliferation. The recent developments in the design of biochips to analyze specihc DNA molecules also take advantage of this technology. Polymer adsorption on patterned surfaces can be used to mimic pattern recognition. This effect can be used to develop sensors and molecular-scale separation processes (66). 

Robinson, B.H., and N.C. Seeman. 1987. The design of a biochip a self-assembling molecular-scale memory device. Protein Engineering 1(4) 295-300. 

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