Biochemical responses, balance with changes

Physiological, pharmacological, and biochemical responses do not usually lead to a tissue lesion, although there may be organ failure as a result. They may result from interactions of chemicals with receptors or specific enzymes leading to anoxia, inhibition of cellular respiration, respiratory failure, changes in pH, temperature, blood pressure or electrolyte balance, for example. 

It is clear from these studies that external mechanical loading not only affects the cellular response through changes in genetic expression by cells, but it also sets into motion a cascade of events that balances cellular biochemical and biomechanical responses with changes in the environmental... 

---