Biocatalytic Reductions of Ketones to Alcohols

Biphasic reaction media, which are advantageous for poorly water-soluble ketones and for reactions at higher substrate concentrations, have been developed for the 

The biocatalytic reduction of the keto group to the alcohol group proceeds with a great tolerance of other functional groups in the substrate, for example, the enantioselective reductions of ketoesters to chiral hydroxyesters [70-73] or of 

2- ketoacids to chiral a-hydroxy acids [74]. The substrate selectivity of transition metal- and lactate dehydrogenase-catalyzed enantioselective reductions of several 

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Figure 1.3 Selected biocatalytic reductions of ketones to alcohols.

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