Bioavailability of polyphenols

Scalbert, A. and Williamson, G., Dietary intake and bioavailability of polyphenols, J. Nutr., 130, 2073S, 2000. 

Silberberg M, Morand C, Mathevon T, Besson C, Manach C, Scalbert A, Remesy C. 2006. The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. Eur J Nutr 45 88-96. 

Comprehensive studies of lea chemistry, the bioavailability of polyphenols, and flavor chemistry... 

The solvent evaporation method can also be used to produce nanoparticles from polylactic polymers, mainly to improve the oral bioavailability of polyphenolics by the oral route. For example, curcumin, EGCG, or ellagic acid has been encapsulated in PLGA nanoparticles, and quercitrin or quercetin has been immobilized in polylactic acid (PLA) nanoparticles, to improve the aqueous solubility, to increase the intestinal absorption, and to increase globally the oral efficacy of these compounds. Ellagic acid in PLGA-PCL nanoparticles was shown to be more active against nephrotoxicity than the free molecule. ... 

Another important limitation is the large interindividual variability that exists in most metabolic responses when given the same dose of components this is a very common situation in the study of bioavailability of polyphenols (Manach et al, 2004 Urpi-Sarda etal, 2005, 2007). 

Scalbert A, Williamson G (2000) Dietary intake and bioavailability of Polyphenols. J Nutr 30 (8S SuppI) 2073S-85S. 

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