Bioactive peptides antihypertensive properties

Bioactive peptides released by enzymatic proteolysis of various proteins that act as potential physiological modulators of metabolism during intestinal digestion have been reported in recent reports. These peptides usually contain 3-20 amino acid residues, and their activity depends on their amino acid composition and sequence (Pihlanto-Leppala, 2001). Based on their structural, compositional, and sequential properties, they may exhibit different kinds of bioactivities such as antioxidative (Jimg et al., 2005 Kim et al., 2001), antihypertensive (Suetsima et ah, 2004), and immunomodulatory effects (Qien et al., 1995 Tsuruki et al., 2003). 

Eisenia species of brown algae. The ACE-inhibitory properties of phlorofu-cofuroeckol A, dieckol, and eckol ranked high, with IC50 values of 12.74 0.15, 34.25 3.56, and 70.82 0.25 pM, respectively. Summarizing, other bioactive compoimds, besides peptides, may be responsible for the antihypertensive capacity of seaweeds. 

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