Mycale adhaerens

Hiburipyranone (82), a brominated isocoumarine from the sponge Mycale adhaerens collected off Hiburi Island, Japan, is cytotoxic against P-388 cells with an IC50 value of 0.19 pg/ml [72]. 

Fusetani, N., Sugawara, T, and Matsunaga, S. (1991). Cytotoxic metabolites of the marine sponge Mycale adhaerens Lambe. J. Org. Chem. 56, 4971 -4974. 

Nishimura, S., Matsunaga, S., Yoshida, M., Nakao, Y, Hirota, H., and Fusetani, N. (2005b) Structure-activity relationship on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens. Bioorg. Med. Chem., 13, 455-462,... 

Uchida, K., Watanabe, H., and Mori, K. (1997) Synthesis of ( )-hiburipyranone, a cytotoxic metabolite of marine sponge Mycale adhaerens. Biosci. Biotechnol. Biochem., 61, 1564-1567. 

---