Bioactive glass composites

Filgueiras M.R.T., LaTorre G., and Hench L.L. 1993. Solution effects on the surface reactions of three bioactive glass compositions. /. Biomed. Mater. Res. 27 1485-1493. 

We mentioned that in steel flbers/bioactive glass composites it was important that there was chemical interaction between the two components to ensure stress transfer during loading. We have just formed a bioceramics company and want to hire you as a consultant. We want you to determine whether such interactions have occurred in a composite we have just made. What analytical technique or techniques would you use for your evaluation Explain the reasoning behind your answer and some of the pros and cons of the technique or techniques you chose. 

Bioactive glass composites Bioactive glass with chitosan-/ -GP, PCL-PLA, PMMA Orthopedic, bone fillers Couto eta/. (2009), Ahoeta/. (2004), Gonzalez Corchon eta/. (2006)... 

Baino F, Verne E, Vitale-Brovarone C. Eeasibility, tailoring and properties of polyure-thane/bioactive glass composite scaffolds for tissue engineering. J Mater Sci Mater Med 2009 20 2189-95. 

Lu, H. H. EL-Amin, S. F. Scott, K. D. Laurencin, C. T. Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite... 

Comparing structural information from X-ray and neutron diffraction provides a very valuable way to validate MD simulation results of glasses. In some simple systems, the partial pair distribution function or partial structure factors of all atom pairs can be determined experimentally and they provide excellent validations for simulated structures. However, as the composition becomes more complicated and more elements included, larger number of pair contributions will complicate the comparison and the validation becomes more and more difficult in multicomponent glass systems. For example, for binary oxides, e.g. sodium silicate, there are six partial pair distribution functions, but for a four component systems, for example the bioactive glass composition, there are a total of fifteen partials contributions. The overlap between partial contributions makes it very challenging to assign the peaks and to determine the quality of comparison and hence the validation of the simulated structure models. 

Zhang, K, Wang, Y, Hdlmyer, M.A., and Francis, L.F. (2004) Processing and properties of porous poly(L-lactide)/ bioactive glass composites. Biomaterials,... 

Figure 43.9 TEM of a mesoporous nanoparticle of a bioactive glass composition.

Mourino, V, Newby, R, Pishbin, F., et al., 2011. PhysicochemicaL biological and drug-release properties of gaUium crossUnked alginate/nanoparticulate bioactive glass composite films. Soft Matter 7, 6705-6712. 

L.-C. Gerhardt, K.L. Widdows, M.M. Erol, C.W. Burch, Y.A. Sanz-Herrera, I. Ochoa, R. Stampfli, I.S. Roqan, S. Gabe, T. Ansari, A.R. Boccaccini, The pro-angiogenic properties of multi-functional bioactive glass composite scaffolds. Biomaterials 32 (2011) 4096 108. 

H.H. Lu, A. Tang, S.C. Oh, J.P. Spalazzi, K. Dionisio, Compositional effects on the formation of a calcium phosphate layer and the response of osteoblast-hke cells on poly-mer-bioactive glass composites, Biomateiials 26 (2005) 6323-6334. 

KiUion, J., et al., 2013. Hydrogel/bioactive glass composites for bone regeneration appbcations synthesis and characterisation. Mater. Sci. Eng. C 33 (7), 4203-4212. Available at http // www.ncbi.nbn.nih.gov/pubmed/23910334 (accessed 05.01.16). 

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