Bioactive bone graft

PLGA Fibroblast growth Direct incorporation and coaxial of BMP-2 for use as bone graft Bioactive nanofibers suitable for different tissue [172]... 

Based on observed tissue response, synthetic bone-graft substitutes can be classified into inert (e.g., alumina, zirconia), bioactive (e.g., hydroxyapatite, bioactive glass), and resorbable substitutes (e.g., tricalcium phosphate, calcium sulfate). Of these, resorbable bone-graft substitutes are preferred for bone defect filling because they can be replaced by new natural bone after implantation, p-tricalcium phosphate (Ca3(PO )2, p-TCP) is one of the most widely used bone substitute material, due to its faster dissolution characteristics. Preparation of magnesium-substituted tricalcium phosphate ((Ca, Mg)3(PO )2, p-TCMP) has been reported by precipitation or hydrolysis method in solution. These results indicate that the presence of Mg stabilizes the p-TCP structure (LeGeros et al., 2004). The incorporation of Mg also increases the transition temperature from p-TCP to a-TCP and decreases the solubility of p-TCP (Elliott, 1994 Ando, 1958). 

Lewandrowski, K.U. et al. Enhanced bioactivity of a poly(propylene fumarate) bone graft substitute by augmentation with nano-hydroxyapatite, Bio-Med. Mater. Eng., 13,115,2003. 

Synthetic bone grafts are available to surgeons, often in the form of bioactive ceramics or glasses. The term bioactive refers to their ability to form a... 

The first-generation bone grafts are metals and alloys (stainless steel, titanium alloys, etc. [1]) which have excellent mechanical properties but are neither bioresorbable nor bioactive. Their lifetime is limited and hence need to be removed and replaced... 

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