Binding in Solution

The factors which affect metal binding in solution may be summarized as  

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Scott, J. E. (1968). Ion binding in solutions containing acid mucopolysaccharides. 

Breuker, K. New mass spectrometric methods for the quantification of protein-ligand binding in solution. Angew. Chem. Int. Ed. 2004, 43,... 

Mulder. A.. Auletta. T., Sartori, A., Del Ciotto, S.. Casnati. A., Ungaro, R., Huskens. J. and Reinhoudt, D.N. (2004) Divalent binding of a bis(adamantyl)-functionalized calix[4]arene to beta-cyclodexti in-based hosts An experimental and theoretical study on multivalent binding in solution and at selfassembled monolayers. J. Am. Chem. Soc., 126,... 

Relative ligand binding in solution of different ligands Si and S2 to a receptor site or enzyme E can be estimated by the free energy perturbation method, using the principle of the thermodynamic cycle (Fig. 3), in which all processes are run with explicit inclusion of water. 

Since binding in solution results from a compromise between interaction with the ligand and solvation, new insights into the origin of the cation recognition process and of the macrocyclic and cryptate effects can be gained from experimental gas phase studies [2.34, 2.35] as well as from computer modelling calculations in vacuo or in a solvent [1.35b, 1.42, 1.43, 1.45, 2.36, 2.37, A.37]. In particular, molecular dynamics calculations indicate that complementarity is reflected in restricted motion of the ion in the cavity [1.45, 2.36]. 

Expanded porphyrins display anion binding in solution and in the solid, a new facet of the chemistry of porphyrin-related macrocycles [3.18]. 

Anion Binding in Solution Sapphyrins, Rubyrins, Anthraphyrins... 

Anion Binding in the Solid State Anion Binding in Solution Sapphyrins, Rubyrins, Anthraphyrins Sapphyrin-Oligonucleotide Interactions... 

L Kotin, M Nagasawa. Chain model for polyelectrolytes. VII. Potentiometric titration and ion binding in solutions of linear polyelectrolytes. J Chem Phys 36 873-879, 1962. 

Following the analogy to the case of receptor/ligand binding in solution, kc can be expressed in terms of rate constants for the diffusive step, k+, and the coupling step, kon ... 

Therefore, we can expect that coupling reactions between two membrane-associated species will commonly be diffusion-limited. This result is in contrast to that for receptor/ligand binding in solution, which will not typically be diffusion-limited, and to that for ligand binding to cell surface... 

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