Binding constants solvation effects

Moreover, it is seen from Table 1.7 that the equilibrium constants at both the nonstereoselective site (fens) and the stereoselective site (fcs) were decreased when the temperature was raised, while concomitantly more nonstereoselective as well as stereoselective adsorption sites became available or accessible at elevated temperatures. The larger number of accessible binding sites at elevated temperatures has been explained by solvation effects The sorbent surface and thus the interaction sites are solvated to a lesser degree so that they are better available for solute interactions [51]. 

What is the exact influence of water and organic molecules on the enzyme structure Could its effects on properties such as selectivity, affinity, binding constants, and catalytic constants be predictable by controlling the hydration/solvation state ... 

Despite the early discovery of the katapinands, non-covalent anion coordination chemistry was relatively slow to develop in comparison with the development of hosts for cations and even neutral molecules. While it is generally true that anion hosts obey the same rules that govern the magnitude of binding constants and host selectivity in cation hosts (primarily based on preorganisation, complementarity, solvation and size and shape effects), their application is made much more difficult because of some of the intrinsic properties of anions, listed below. 

Thus, according to Sahai and Sverjensky, the binding constants for monovalent cations and anions can be calculated when their crystallographic ionic radii and the dielectric constant of the adsorbent are known. Moreover, an empirical equation was proposed to calculate the inner capacitance as a function of the aqueous solvation coefficient and aqueous effective radius. These two parameters depend only on the nature of the 1-1 salt, but they are independent of the adsorbent, and the C] values are listed in Table 5.20. 

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