Bilirubin clearance

Rdllinghoff, W., Paumgartner, G., Preisig, R. Nicotinic acid test in the diagnosis of Gilbert s syndrome correlation with bilirubin clearance. Gut 1981 22 663-668... 

This anticoagulant drug causes inhibition of bilirubin clearance and conjugation (H5) as well as inhibition of S-aryl glutathione transferase (B38). The action of this drug on dye excretion has not been reported. 

Assenat, E., Gerbal-Chaloin, S., Larrey, D., Saric, J., Fabre, J. M., Maurel, P., Vilarem, M. J., and Pascussi, J. M. (2004) Interleukin lbeta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 40, 951-960. 

D. D. (2003) Induction of bilirubin clearance by the constitutive androstane receptor. Proc. Natl Acad. Sci. USA 100, 4156-4161. 

The VP-CAR mice were also used to demonstrate the effect of CAR activation on bilirubin clearance. No differences in serum bilirubin levels were seen in untreated VP-CAR or wild-type mice. However, upon bilirubin injection, the levels of total bilirubin in the transgenic mice were less than half of those in wild-type mice [25], The protection was VP-CAR dependent, as no protection was seen in mice treated with Dox for 7 days prior to bilirubin injection [25]. Consistent with their resistance to... 

In the context of the treatment of acute OP pe.sticide poisoning, the acute toxicity is the only consideration of importance. The acute toxicity of PAM salts and of obidoxime is of the same order of magnitude. Impaired liver function has been observed after treatment of human parathion poisoning with obidoxime (Barckow etal., 1969 Wirth, 1968), and reversible fatty change has been reported in the liver of rats treated with that oxime BLsa ei al., 1964). However, Boelcke and Gaaz (1970) did not find evidence of hepatotoxicity in mice in terms of en ,yme elevation, and bilirubin clearance and bromsulfthalcin retention were unaffected in the rat (Boelcke and Kamphenkel, 1970). Therefore, some or all of the hepatotoxicity of obidoxime may be attributable to other factors, such as the OP or solvents. 

Recently this type of study has been undertaken in order to quantitate ineffective erythropoiesis in normal subjects [393] and in patients with a variety of haematological disorders [387]. In these investigations the incorporation of [ N]glycine into early labelled bilirubin and haemoglobin haem was measured. [ Cj Bilirubin clearance was used to estimate total bilirubin production rate [394], and hepatic haem turnover was calculated from the incorporation of a-amino [ N]laevulinic acid into early labelled bilirubin. The relative contribution of ineffective erythropoiesis in the production of anaemia found in these... 

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