Bile Acids Increase Mutant Cells in the GI Tract

5 Bile Acids Increase Mutant Cells in the GI Tract 

The observation that bile acids cause DNA damage (Table 3.4) suggests that bile acids should increase the frequency of mutation since unrepaired DNA damage causes replication errors. Table 3.5 lists the studies showing that bile acids cause an increase in mutant cells in the GI tract. In vitro, DOC treatment 

Target organjtissuejcell Bile acid(s) Evidence for induced mutation References 

Esophagus (squamous carcinoma KYSE-30 cells) DOC Increase in p53 mutations 8 

Esophagus (Big Blue FI lad transgenic rats) Increased duodeno-gastric-esophageal reflux Significant increase in lad mutations 43 

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