Biguanides properties

The ultraviolet spectra of a number of substituted arylbiguanides have been recorded and the effects of various substituents in both the aryl and biguanide moiety examined 608) (see Table 5). SimUaiities in the absorption properties of arylbiguanides and acetanilides are noteworthy. 

In the following Sections the chemical properties of biguanide and its derivatives are systematically considered. Attention may be drawn to the particularly extensive and detailed recent studies concerning biguanides... 

The reactions of acetylene, including its polymerisation, that occur in the presence of cupric chloride solution have been studied 670) in the (additional) presence of biguanide dihydrochloride. This solution has the unique property of promoting the formation of acetic acid from acetylene. 

Biguanides have been used for a variety of purposes in medical practice but their clinical importance is undoubtedly dominated by their valuable antimalarial and oral hypoglycemic properties. These functions have been closely studied in an effort to gain an imderstanding of the mode of... 

Gelbard, G. Vielfare-Joly, F. Polynitrogen Strong Bases 1-New Syntheses of Biguanides and Their Catalytic Properties in Transesterification Reactions, Tetrahedron Lett. 1998,39, 2743-2746. 

A short review of the uses of polymeric and immobilised guanidines and biguanides is given along with recent results on the preparation and properties of biguanides. 

The polystryrene-bound biguanides were checked under exactly the same conditions and exhibited excellent catalytic properties (Table 1). The immobilization of the biguanide units induced only a very limited decrease in the reactivity. Yields above 90% were obtained in less than 15 mn. The yields of methyl esters are above 94% even before 15 mn reaction time. 

A well-developed coordination chemistry of the chelating biguanide (234) (big) ligand has been reviewed,but the prevalence of hydrates and the acid-base properties of the coordinated ligand has caused confusion in the structural assignment. The two series of salts [M(big)3]-xH20... 

Gelbard, G. and Vielfaure-Joly, F. (1998) Polynitrogen strong bases 1- New syntheses of biguanides and their catalytic properties in transesterification reactions. Tetrahedron Letters, 39, 2743-2746. 

---