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Biguanide antidiabetic agents

Describe the mechanism of action of biguanide antidiabetic agents. [Pg.237]

The activity of compounds incorporating the biguanide function as oral antidiabetic agents has been alluded to previously. [Pg.221]

NONCYCLIC ALIPHATICS Many of the biguanides have oral hypoglycemic activity, and metformin (87) is such an antidiabetic agent. Cyanamide has a highly reactive nitrile function because of the electropositive NH2 group... [Pg.20]

The guanylthiourea (316) reacted with butylamine in the presence of silver nitrate or mercuric chloride at room temperature to give the biguanide etoformin (317) Scheme 5.71.) [387]. The compound was claimed to be an antidiabetic agent with a better therapeutic ratio than phenformin or buformin. [Pg.263]

Yet another example of a so-called pharmacophoric group is the biguanide functionality, a grouping associated with oral antidiabetic activity (see the section on sulfonylureas for a fuller discussion of this activity). Condensation of 2-phenethylamine with dicyanamide affords directly the orally active hypoglycemic agent phenformin (88). ... [Pg.75]

See other pages where Biguanide antidiabetic agents is mentioned: [Pg.80]    [Pg.74]    [Pg.521]    [Pg.1428]    [Pg.350]    [Pg.939]    [Pg.128]    [Pg.1903]    [Pg.2]    [Pg.47]    [Pg.1343]    [Pg.9]    [Pg.93]    [Pg.377]    [Pg.73]    [Pg.74]    [Pg.675]    [Pg.998]    [Pg.196]    [Pg.240]   
See also in sourсe #XX -- [ Pg.228 ]



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Biguanide

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