Bifunctional ligand

The functional groups outlined in Fig. 10 are all bifunctional ligands that can, at least from a theoretical point of view, form monomeric, dimeric, or oligomeric complexes with metal ions or a diorganoboryl group. 

Develop bifunctional ligands which NCI, NIH have a high affinity for Pb(ll) and Bi(lll) systematic exploration of incorporating thiol donor groups into chelating agents... 

However, problems are encountered in production of rhenium radionuclides and work is being done to increase the yields of the radionuclides to meet urgent demands for their use in therapy. Moreover, rhenium is not as reactive as technetium. This situation makes rhenium chemistry somewhat specific - optimum conditions in the preparation of rhenium complexes or in antibody labeling using bifunctional ligands must be identified. 

Bifunctional ligands containing alkoxy groups can be used for anchoring metal complexes to surface OH groups through a longer alkyl chain (Scheme 7.16).249-251... 

Similar, but more extensive, studies of the co-ordination behaviour of the bifunctional ligands (70a) and (70b) with a range of metals have revealed both P,N and P,P bonding. For the Pd" complexes [PdXjL] (X = Cl, Br, or I), i.r. data indicate that both ligands employ P,P co-ordination. The choice of donor atom is discussed in terms of chelate ring size and stereochemical preferences of the various metals. "... 

Acid derivatives of saccharides constitute relevant bifunctional ligands, well suited for stabilization of five-membered oxo-Cr(V) chelates, since they provide both 2-hydroxy- 1-carboxylate and vic-diol sites for potential chelation.19,50,92... 

Treating a mixture of (S,S)-15F and (R,f )-15F with Zn(OAc)2 affords the pseudo-C2-symmetric complex SAL 16FF (Figure 9.9). The reaction is trivial mix the two diastereomeric bifunctional ligands (15F) with Zn(OAc)2, remove the solvent (CH2Cl2/MeOH), triturate with methanol, and wash the resulting solid with methanol. 

Annunziata, R., Benaglia, M., Cinquini, M. and Cozzi, F. (2001) Synthesis of a bifunctional ligand for the sequential enantioselective catalysis of various reactions. Eur. J. Org. Chem., 1045-1048. 

Two molecules of the acid chloride of l,10-phenanthroline-2-carboxylic acid have been condensed with a number of diamino compounds such as o-phenylenediamine to give novel bifunctional ligands.361 More examples of the decarboxylation of carboxy-substituted... 

A detailed examination of the reactivity of organo-aluminium derivatives of 0,0-bifunctional ligands has been undertaken,559 and the effect of substituents on the reversible rearrangements of chlorophosphane-dichlorogermylene ylides to trichloro-germylphosphanes has been investigated.560... 

Kannan, S. Chetty, K.V. Venugopal, V. Drew, M.G.B. Extraction and coordination studies of the unexplored bifunctional ligand carbamoyl methyl sulfoxide (CMSO) with uranium(VI) and cerium(III) nitrates. Synthesis and structures of [U02(N03) 2(PhSOCH2CONiBu2)] and fCe(NOi)i(PhSOCn2CONBLi2)2, Dalton Trans. (2004) 3604-3610. 

Bifunctional Cs-isoprenoid allylamines, isomerization, 10, 72 Bifunctional ligand hydrogenation catalysts, in organometallic synthesis, 1, 79... 

Milanesi, L., Hunter, C.A., Sedelnikova, S.E., Waltho, J.P. Amplification of bifunctional ligands for calmodulin from a dynamic combinatorial library. Chem. Eur. J. 2006, 12, 1081-1087. 

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