Bicarbonate ion from carbon dioxide

Mechanism of Action A carbonic anhydrase inhibitor that reduces formation of hydrogen and bicarbonate ions from carbon dioxide and water by inhibiting, in proximal renal tubule, the enzyme carbonic anhydrase, thereby promoting renal excretion of sodium, potassium, bicarbonate, and water. Ocular Reduces rate of aqueous humor formation, lowers intraocular pressure. Therapeutic Effect Produces anticonvulsant activity. 

Ab initio MO-LCAO-SCF methods have been applied to the formation of the bicarbonate ion from carbon dioxide and hydroxide ion. It is concluded that in the gas phase there should be no barrier to reaction, and that in solution solvation of the hydroxide ion reduces reactivity. The authors speculate that the high activity of carbonic anhydrase may be due to an unsolvated hydroxide in Zn—OH in a hydrophobic environment. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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