Biaryl-1,2,3-triazoles

Biaryl-1,2,3-triazoles have been reported to undergo direct palladium-catalyzed arylation to yield annulated phenanthrenes."... 

A potentially profitable discovery was that dibromide 74 will undergo an Ullman-type coupling to give the corresponding bis(l,2,4-triazole) 76 in 51% the reaction conditions employed were chosen in order that a trifluoromethyl substituent could be introduced but this reaction did not occur, the biaryl bond formation being preferred (Equation 27) <2006T3301 >. 

Kaboudin B, Mostafalu R, Yokomatsu T (2013) FejO nanoparticle-supported Cu(ll)-p-cyclodextrin complex as a magnetically recoverable and reusable catalyst for the synthesis of symmetrical biaryls and 1,2,3-triazoles from aryl boronic acids. Green Chem 15 2266-2274 Roy S, Chatteijee T, Islam SM (2013) Polymer anchored Cu(II) complex an efficient and recyclable catalytic system for the one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles starting from anilines in water. Green Chem 15 2532-2539... 

Later on, Uozumi and co-workers developed a highly enantioposition-selective Cu(I)-catalyzed azide-alkyne cycloaddition of benzyl azide with dialkynes bearing prochiral biaryl groups, which provides a novel and efficient protocol to obtain 1,2,3-triazole derivatives bearing axially chiral biaryl groups with high enantios-electivities (Scheme 37) [62]. 

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